Da Brat was born on April 14, 1974 in Chicago, Illinois,^[3][4][5] and was raised primarily on the West Side of the city.^[6] Her father is David Ray McCoy, a businessman, and her mother, Nadine Brewer, was a city bus driver.^[7][8] Her parents never married, and Brat was subsequently raised in two different households. She lived part-time with her mother, and part with her grandmother, attending an Apostolic church four times a week and singing in the choir. Brat is the paternal half-sister of actress LisaRaye "Lisa Raye" McCoy. Da Brat attended Kenwood Academy during her sophomore and junior year, where she ran track and played basketball. She graduated from the Academy of Scholastic Achievement, a continuation charter school that caters to at-risk students in 1992.^[9]

In 1992, Da Brat's big break occurred when she won the grand prize in a local rap contest sponsored by Yo! MTV Raps. As part of her prize, Brat met the young rap duo Kris Kross and was introduced to their producer, Jermaine Dupri; Brat was eventually signed to his So So Def label, with Dupri remaining a collaborator, friend and fixture throughout the entirety of Brat's career. Her debut album, Funkdafied (1994), entered the Billboardhip hop albums chart at #11. The album went platinum, making her the first solo female rapper to exceed one million records sold. The album's lead single, "Funkdafied", reached #1 on the Billboard Hot Rap Songs chart and #6 on the Billboard Hot 100. Her follow-up single from the album, "Give It 2 You", reached #26 on the Hot 100.^[10]

The Essence article "Da Brat's Best Fashion Looks" highlights the evolution and impact of Da Brat's unique style throughout her career. It showcases her distinctive fashion choices, blending hip-hop culture with personal flair, making her a fashion icon. The article features her signature looks, such as iconic braids and oversized jerseys, emphasizing how her bold style complements her musical career and influences the fashion industry. Da Brat's fearless approach to fashion has inspired many, solidifying her role in shaping hip-hop fashion and beyond.^[11]

In 1996, Da Brat released her second full-length album, Anuthatantrum, which included the single "Ghetto Love" featuring T-Boz of TLC. Over the course of the 1990s, Brat came to be recognized for her comedic timing, her laidback attitude, and her many memorable guest-spots on other artists' songs. She was featured with Kris Kross on the title track of their album Da Bomb (1993), as well as on their third album, Young, Rich and Dangerous (1996). A long-time friend of singer Mariah Carey, Brat contributed a rap verse to the So So Def remix of Carey's #1 single "Always Be My Baby" in 1996, which also featured Dupri and fellow So So Def group Xscape. That same year, Brat made her feature film debut in Kazaam(1996), starring Shaquille O'Neal. 

The late 1990s saw Da Brat featured in many high-profile collaborations, including her appearance on a remix of Dru Hill's 1997 song "In My Bed". That same year, she and Dupri also appeared on a remix of Mariah Carey's #1 single "Honey", entitled "Honey (So So Def mix)"; Brat also recorded a hit remix of "Ladies' Night (Not Tonight)" with Lil' Kim, Lisa "Left-Eye" Lopes (of TLC), Angie Martinez, and Missy Elliott. The quintet gave an Ancient Egypt/Roman-themed performance of the song at the 1997 MTV Video Music Awards. Brat was then featured in "Sock It 2 Me" by Elliott, off of her debut album Supa Dupa Fly (1997), and starred in its accompanying music video. In 1999, she was featured with Krayzie Bone (of Bone Thugs-n-Harmony) on Carey's "I Still Believe (Imagination Remix)", originally by Brenda K. Starr; the remixed version creatively samples the melodies of "Pure Imagination", originally performed by Gene Wilder in Willy Wonka & the Chocolate Factory (1971). That same year, Brat was featured again with Missy Elliott on Mariah Carey's remix of "Heartbreaker" (1999), and starred in the accompanying music video. She also joined Carey for several televised promotional performances, including on TheOprah Winfrey Show. The remix samples the song "Ain't No Fun (If the Homies Can't Have None)" (1993) by Snoop Dogg, who also appears in the music video, and Brat composed her verses loosely based on the original. By the end of 1999, she had also contributed a verse to the remix of Brandy's "U Don't Know Me (Like U Used To)", as well as to a remix of the Destiny's Child hit "Jumpin', Jumpin'".

In early 2000, Da Brat released her third full-length album, Unrestricted, preceded by the single "That's What I'm Looking For" (U.S. #56), which was featured on the soundtrack to Big Momma's House (2000). She also released "What'chu Like" (U.S. #26), featuring R&B singer Tyrese. The album was not as well-received as Brat's earlier work. However, the record and the new millennium saw an image change for Da Brat, deviating from her "gangsta", tomboy persona, and deciding to follow the "sexy" trend in popular music. The new album featured Da Brat reciting more forward, sexually-charged lyrics and wearing more revealing, feminine outfits. In 2001, Brat continued being featured on other artists' songs, reaching #1 on the Billboard Hot R&B/Hip Hop Singles chart (along with Cameo and rappers Ludacris and Shawnna) on the remix of Mariah Carey's "Loverboy". The same year, she was featured on Destiny's Child's "Survivor" remix. Da Brat also appeared as friend Louise in Carey's 2001 movie Glitter. In 2003, Brat released her fourth album, titled Limelite, Luv & Niteclubz, including the single "In Love wit Chu" which peaked at peaked at #9 on the Billboard rhythmicchart. At the same time, she appeared on the fourth season of VH1's The Surreal Life.