• Dr. Edward Omane Boamah – Defence
• Samuel Nartey George (MP) – Communication, Digital Technology, and Innovations
• Emmanuel Armah-Kofi Buah (MP) – Lands and Natural Resources
• Kofi Iddie Adams (MP) – Sports and Recreation
• Abdul-Rashid H. Pelpuo (MP) – Labour, Jobs and Employment
• Kwabena Mintah Akandoh (MP) – Health
• Ibrahim Murtala Muhammed (MP) – Environment, Science and Technology
• Joseph Bukari Nikpe (MP) – Transport
• Muntaka Mohammed-Mubarak (MP) – Interior
• Samuel Okudzeto Ablakwa (MP) – Foreign Affairs
• Adjei Kenneth Gilbert – Works, Housing, and Water Resources
• Emmanuel Kwadwo Agyekum (MP) – Minister of State in Charge of Special Initiatives
• Felix Kwakye Ofosu (MP) – Government Communications
• Issifu Seidu (MP) – Minister of State, Climate Change, and Sustainability

Regional Ministers

On Tuesday, January 14, 2025, President Mahama announced his first 10 regional ministers-designate. He added three more on Thursday, January 16, 2025, and the final three on Tuesday, January 21, 2025, bringing the total number of regional ministers to 16. They are:

• Puozuing Charles Lwanga – Upper West
• Joseph Addae Akwaboa – Bono
• Francis Owusu Antwi – Bono East
• Wilbert Petty Brentum – Western North
• Eduamoah Ekow Panyin Okyere – Central
• Joseph Nelson – Western
• Ali Adolf John – Northern
• John Kwadwo Gyapong – Oti
• James Gunu – Volta
• Mrs. Rita Akosua Adjei Awatey – Eastern
• Ibrahim Tia – North East
• Dr. Frank Amoakohene – Ashanti
• Akamugri Donatus Atanga – Upper East
• Charity Gardiner – Ahafo
• Salisu Be-Awuribe – Savannah
• Linda Ocloo (MP) – Greater Accra