President John Dramani Mahama stated that Ghana would not be a transit or destination for illegal drugs or drug business. This strict warning is made after recent occurrences and reports putting Ghana on the global drug map.

A huge operation at the Tema Port in March 2025 led to the confiscation of opioid drugs worth approximately GH₵20 million. The seized consignment said to be destined for Niger had enormous quantities of Tapentadol and other chemicals. The Health Minister, Kwabena Mintah Akandoh, ensured that while Ghana will not impede trade, it will not be a haven for illegal opioids either. He assured the citizens that President Mahama himself is personally taking care of the situation and curbing the circulation of such drugs. Ghana has in the past been identified as a drug transit point. In June 2022, the British High Commission clarified that the country was on the world's watch list as a transit route for cocaine and other psychotropic drugs, with some fishing communities being associated with the supply chain. The British High Commission Deputy Head of Missions, Keith McMahon noted that it was important to take immediate action to cut off such supply lines.

However, Ghanaian authorities have challenged some of these claims. In July 2017, the Acting Central Regional Commander of the Narcotics Control Board (NACOB) Riis Kofi Oduro debunked a United Nations report ranking Ghana as the third transit destination in Africa for cocaine. He argued that the report did not compare with NACOB's findings and advised the utilization of accurate data when responding to the nation's drug issues.

The latest statement by President Mahama underlines the commitment of the government to curb drug trafficking and keep Ghana from becoming a transit hub for illicit drugs. The government is ramping up efforts to close the nation's ports and borders and monitor the export and importation of goods to ensure the integrity of the nation and public health.

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