They generally missed the 1-1 first-leg attract Spain, when Dani Parejo leveled Dusan Vlahovic's initial opener for Juve.

Massimiliano Allegri accepts the threesome could give Juventus the edge, regardless of whether none are adequately fit to begin.

"Replacements will be vital," said the Juventus chief.

"Chiellini, Dybala and Bernardeschi don't have an hour and a half in their legs so they can be quality replacements for us."

Villarreal manager Unai Emery is evaluating the wellness of his own key striker, Spain worldwide Gerard Moreno, who has been out since early February with a calf injury.

The previous Arsenal and Paris St-Germain administrator is quick to lay out Villarreal as a Champions League club subsequent to directing them to triumph over Manchester United in the Europa League last season - his fourth triumph as director in the opposition.

"We don't need Villarreal to be a transient thing in the Champions League, we need to be digging in for the long haul," he said.

"Winning against a club like Juventus implies the chance to continue to contend at the European level. We need to work around characterized structures so we can remain here long haul... It's brilliant to be in the Champions League and we would rather not leave."

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