The premier league club said the 28 year-old has ruptured a ligament, but will not require surgery.
Rob Price who is the doctor for Leeds United added that bamford has had the entry for 12 months and will be out for at least 6 weeks.
"Despite treatment and a prolonged period of rehabilitation, the entry has progressed from a partial tear to a full rapture", said price.
With only eight weeks of the season left bamford will struggle to make a return as 16 placed Leeds fight against relegation.
it is the latest setback for the England international who returned as a goal-scoring substitute in December 2-2 draw against Brentford after injuring his ankle in September.
Patrick bamford last played for the club in the 3-2 win over wolves United Molineux on 18th March, when he was taking off after 23 minutes with the problem, which affects the sole of his foot.
Leeds United have been boosted, though, with news that captain Liam Cooper, fellow centre-back Diego Llorente can midfielder kalvin Phillips have all returned to training and will be available to face Southampton on 2nd April.
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