Kylian Mbappe splendidly twisted the ball into the top corner for the principal objective and Olivier Giroud added a second with a low shot after great footwork.
Lucas Digne and Mbappe both hit the crossbar before Mbappe changed over a punishment after he had been fouled.
Wissam Ben Yedder scored a fourth from Paul Pogba's header with Matteo Guendouzi netting a fifth late on.
South Africa, who have not qualified for the 2022 World Cup, finished the coordinate with 10 men. Khuliso Mudau was shipped off with six minutes staying after a video associate arbitrator check showed he had fouled Aston Villa protector Digne.
Ex-Arsenal and Chelsea striker Giroud, 35, is presently on 48 objectives for France from 112 matches, just three shy of Thierry Henry's record of 51 objectives from 123 games.
France won the World Cup briefly time in 2018 and have just been beaten once in 20 matches - in the last 16 of the previous summer's Euro 2020 when they lost on punishments to Switzerland.
Didier Deschamps' side stayed unbeaten all through their World Cup qualifying bunch as they got their place in Qatar and are right now third in Fifa's reality rankings - behind Belgium and Brazil.
In their present winning run they have likewise beaten Finland two times, Belgium, Spain, Kazakhstan and Ivory Coast.
Mbappe has been instrumental in that run and has now scored multiple times in his beyond five internationals.
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