The occasion in the city of Highland Park, Illinois, was abruptly ended not long after 10:00 neighborhood time (15:00 GMT), when a few shots were heard.
24 individuals were taken to clinic, authorities say.
A suspect has been named as Robert E Crimo III, 22. Police said he is viewed as equipped and risky. Police said the suspect seemed to have designated the motorcade's participants at irregular with a powerful rifle.
The thought shooter started shooting at the motorcade at around 10:15 nearby time, only a couple of moments after it started.
The occasion was planned to incorporate floats, walking groups, and local area amusement as area of the city's Independence Day festivities.
However, what ought to have been one of the most joyful days of the year immediately went to overreact, with pushchairs, satchels and loungers left disposed of in the city as groups ran away from the area.
The suspect is accepted to have terminated at individuals from general society from the roof of a close by shop, where police say they recuperated "proof of a gun."
Five grown-ups were killed at the scene, as well as a further casualty who the neighborhood coroner expressed kicked the bucket in a close by medical clinic.
"On a day that we met up to commend local area and opportunity, we're rather grieving the unfortunate death toll," said city chairman Nancy Rotering.
The Fourth of July is a public occasion denoting the date the American states pronounced freedom from Great Britain in 1776. Observers at the scene depicted the frightening second they heard different shots discharged one after another.
Anand, who said he was under 100m (328ft) from the shooter, told the BBC he at first thought he had heard a vehicle misfiring before he saw others running and acknowledged what was unfurling.
It was "the sort of firearm where it delivers a ton of slugs in an exceptionally short measure of time. Inconceivably boisterous. Then there's finished quietness," he said.
Weapon savagery is extremely uncommon in this rural region, he added: "I had a good sense of reassurance here and this is exceptionally dreamlike. We're concealing in a sanctuary currently being careful, there's kin crying. It's anything but a positive sentiment, by any means."
Another observer, Noel Hara, portrayed how he was eating at Starbucks subsequent to dropping off his child at the procession, when the confusion unfurled.
"Around 30 individuals out of nowhere came surging in shouting and we were gotten into the Starbucks washroom," Mr Hara told the BBC.
"Minutes after the fact, they cleared us from the Starbucks on the grounds that they thought the shooter was attempting to get in the secondary passage."
Mr Hara was in the end ready to rejoin with his child subsequent to following his developments on an area following application.
Hours after the assault police are as yet looking for the suspect, utilizing police canines and robots to zero in their examination on the motorcade course, the midtown region and the focal business locale.
Those residing there, depicted by police as an "functioning crime location", were encouraged to shield set up.
Weapon brutality in Chicago will in general ascent over occasion ends of the week as the blistering weather conditions sends individuals outside. In 2021, in excess of 100 individuals were shot and 17 killed over the Fourth of July weekend in the city of Chicago.
The shooting comes simply a month after the dangerous shootings in Uvalde, Texas and Buffalo, New York - and seven days after the US Congress passed bipartisan regulation on weapon control in America.
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