Patience Ozokwo was born in the village of Amaobo, Ngwo in present-day Enugu State, Nigeria, and attended Abimbola Gibson Memorial School in Lagos. Patience Ozokwor had a passion for acting ever since she was in primary school, where she would act in different stage plays.^[7] She later attended the Institute of Management and Technology Enugu, where Patience obtained a degree in fine and applied arts. Before starting as an actress, she was part of a Radio Drama.^[8] She took part in a soap opera by the Nigerian Television Authority (NTA) titled "Someone Cares".^[9][10] She was married at age 19^[11] and has three biological children and five adopted ones, who all bear her name. Ozokwor became a widow in 2000 when she lost her husband.^[12][13]

She was an announcer and broadcaster on Radio Nigeria before she became an actress. She rose to fame from her role in the 1999 movie titled Authority and her first TV drama won a soap opera titled Someone Cares on the Nigerian Television Authority (NTA).^[8] Since her rise to fame, she proceeded to act in over 100 movies.^[14][15]

She recently starred in the Mo Abudu Netflix movie Chief Daddy (2018) and Chief Daddy 2: Going for Broke (2022) as Madam Pat.

She got married at the age of 19 and she lost her husband to a terminal disease.^[16] She has three biological children, five adopted children and grand children.^[17] She is also an ordained evangelist.^[5]