City leads Liverpool by six points with one game remaining after a win that was probably even more impressive than the score suggests.
Ralf Rangnick's team was without injured Cristiano Ronaldo and Edinson Cavani, as well as Raphael Varane and Luke Shaw, who both have Covid-19, and were outclassed by the reigning champions' talent and effort.
Kevin de Bruyne was the driving force behind it all. He put City ahead early on with a neat finish, then restored their advantage just before half-time when Jadon Sancho equalized for United with a low strike, the Belgian's second smashed in in a goalmouth melee.
After the break, City picked up the pace and deservedly scored after 68 minutes when Riyad Mahrez met De Bruyne's corner on the half-volley to past United goalkeeper David de Gea. The goal came as a result of a deflection off United captain Harry Maguire, who had a terrible afternoon.
City's fortunes improved in the final minutes as Mahrez sprinted clear to beat De Gea, the goal being awarded after a lengthy VAR probe for offside.
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